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Principles and practice of hospital medicine 2nd edition Download principles and practice of hospital medicine 2nd edition or read online here in PDF or EPUB. Please click button to get principles and practice of hospital medicine 2nd edition book now. All books are in clear copy here, and all files are secure so don't worry about it. The Principles and Practice of Hospital Medicine book is divided into six parts: Systems of Care: Introduces key issues in hospital medicine, patient safety, quality improvement, leadership and practice management, professionalism and medical ethics, medical legal issues and risk management, teaching and development.
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For nearly 30 years, Dr. Meir Kryger’s must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. For this updated 6th edition, extensive additional online material enhances the value of Principles and Practice of Sleep Medicine to your practice.
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Evidence-based content helps you make the most well-informed clinical decisions.
An ideal resource for preparing for the sleep medicine fellowship examination.
New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women’s health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date.
Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders.
Online access to additional resources, including 95 video clips and over 950 self-assessment questions.
The essential reference tool to manage and diagnose patients with sleep disorders.
An ideal resource for preparing for the sleep medicine fellowship examination.
New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women’s health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date.
Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders.
Online access to additional resources, including 95 video clips and over 950 self-assessment questions.
The essential reference tool to manage and diagnose patients with sleep disorders.
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Harrison's Principles Of Medicine
Perhaps my favorite phrase to parents welcoming home a newborn is: “Don’t blink!” In what seems like only a moment in time, parents are suddenly reflecting on how quickly their child has grown: talking, walking, in school, driving, perhaps college, relationships, jobs, their own kids? As this sixth edition of Principles and Practice of Sleep Medicine is published, my question to Drs. Kryger, Roth, and Dement is: “Did you blink?”
Who could have imagined that Principles and Practice of Sleep Medicine would grow to 21 distinct sections that include 171 chapters? Te breadth, depth, and quality represented by the scientifc and clinical knowledge in this text are quite amazing. Peruse the range of topics covered across those 21 sections: normal sleep, sleep mechanisms, and phylogeny to why we dream to occupational sleep medicine to the classics of sleep medicine (insomnia, sleep disordered breathing, parasomnias, and narcolepsy). Ten consider the depth of knowledge represented: 16 chapters on sleep-disordered breathing, 12 each on physiology in sleep and instrumentation and methodology, and even the “newest” areas, such as genetics and genomic basis of sleep (6 chapters) and legal topics in sleep medicine (5 chapters) have enough content for multiple chapters
Who could have imagined that Principles and Practice of Sleep Medicine would grow to 21 distinct sections that include 171 chapters? Te breadth, depth, and quality represented by the scientifc and clinical knowledge in this text are quite amazing. Peruse the range of topics covered across those 21 sections: normal sleep, sleep mechanisms, and phylogeny to why we dream to occupational sleep medicine to the classics of sleep medicine (insomnia, sleep disordered breathing, parasomnias, and narcolepsy). Ten consider the depth of knowledge represented: 16 chapters on sleep-disordered breathing, 12 each on physiology in sleep and instrumentation and methodology, and even the “newest” areas, such as genetics and genomic basis of sleep (6 chapters) and legal topics in sleep medicine (5 chapters) have enough content for multiple chapters
Contentsxl Contents
27 Genetics and Genomics of Circadian
Clocks 272
Martha Hotz Vitaterna, Fred W. Turek, and
Peng Jiang
28 Genetics and Genomic Basis of Sleep
in Simple Model Organisms 281
Ravi Allada and Mark Wu
29 Genetics and Genomic Basis of Sleep in
Rodents 296
Bruce F. O’Hara, Peng Jiang, Fred W. Turek,
and Paul Franken
30 Genetics and Genomic Basis of Sleep in
Healthy Humans 310
Hans-Peter Landolt and Derk-Jan Dijk
31 Genetics and Genomic Basis of Sleep
Disorders in Humans 322
Allan I. Pack, Brendan T. Keenan, Enda M. Byrne,
and Philip R. Gehrman
Section 5
Chronobiology 340
32 Introduction: Master Circadian Clock
and Master Circadian Rhythm 340
Fred W. Turek and Phyllis C. Zee
33 Anatomy of the Mammalian Circadian
System 343
Joshua J. Gooley and Clifford B. Saper
34 Physiology of the Mammalian Circadian
System 351
Alan M. Rosenwasser and Fred W. Turek
35 Human Circadian Timing System and
Sleep-Wake Regulation 362
Charles A. Czeisler and Orfeu M. Buxton
36 Sleep Homeostasis and Models of Sleep
Regulation 377
Peter Achermann and Alexander A. Borbély
37 Circadian Rhythms in Sleepiness,
Alertness, and Performance 388
Rylie J. Gabehart and Hans P.A. Van Dongen
38 Central and Peripheral Circadian Clocks 396
Edith Grosbellet and Etienne Challet
39 Circadian Dysregulation in Mental and
Physical Health 405
Sabra M. Abbott, Roneil G. Malkani, and
Phyllis C. Zee
40 Circadian Disorders of the Sleep-Wake
Cycle 414
Sabra M. Abbott, Kathryn J. Reid, and
Phyllis C. Zee
Section 6
Pharmacology 424
41 Hypnotic Medications: Mechanisms of
Action and Pharmacologic Effects 424
Thomas S. Kilduff and Wallace B. Mendelson
42 Clinical Pharmacology of Other Drugs
Used as Hypnotics 432
Daniel J. Buysse and Shachi Tyagi
43 Wake-Promoting Medications: Basic
Mechanisms and Pharmacology 446
Seiji Nishino and Emmanuel Mignot
44 Wake-Promoting Medications: Efcacy
and Adverse Effects 462
Mihaela Bazalakova and Ruth M. Benca
45 Drugs that Disturb Sleep and Wakefulness 480
Paula K. Schweitzer and Angela C. Randazzo
46 Effects of Hypnotic Drugs on Driving
Performance 499
Joris C. Verster, Aurora J.A.E. van de Loo,
and Thomas Roth
Section 7
Psychobiology and Dreaming 506
47 Introduction 506
Robert Stickgold
48 Why We Dream 509
Robert Stickgold and Erin J. Wamsley
49 Dream Content: Quantitative Findings 515
Antonio Zadra and G. William Domhoff
50 Brain Correlates of Successful Dream
Recall 523
Luigi De Gennaro and Michele Ferrara
51 Neurobiology of Dreaming 529
Edward F. Pace-Schott and Dante Picchioni
52 Lucid Dreaming 539
Martin Dresler, Daniel Erlacher, Michael Czisch,
and Victor I. Spoormaker
53 Nightmares and Nightmare Function 546
Tore Nielsen and Michelle Carr
54 Incorporation of Waking Experiences
into Dreams 555
Michael Schredl
55 Dreams and Nightmares in
Posttraumatic Stress Disorder 561
Wilfred R. Pigeon and Thomas A. Mellman
56 Emotion, Motivation, and Reward in
Relation to Dreaming 567
Sophie Schwartz and Lampros PerogamvrosContents xli
PAR T II
Practice of Sleep Medicine 571
Section 8
Impact, Presentation, and Diagnosis 573
57 Approach to the Patient with Disordered
Sleep 573
Beth A. Malow
58 Cardinal Manifestations of Sleep
Disorders 576
Bradley V. Vaughn and O’Neill F. D’Cruz
59 Physical Examination in Sleep Medicine 587
Alon Y. Avidan and Meir Kryger
60 Use of Clinical Tools and Tests in Sleep
Medicine 607
Cathy A. Goldstein and Ronald D. Chervin
61 Classifcation of Sleep Disorders 618
Michael J. Sateia and Michael J. Thorpy
62 Epidemiology of Sleep Medicine 627
Amy W. Amara and Mary Halsey Maddox
63 Sleep Medicine, Public Policy, and
Public Health 638
Raghu Pishka Upender
64 Sleep and Athletic Performance 646
Scott J. Kutscher
Section 9
Legal Topics in Sleep Medicine 653
65 Sleep Forensics: Criminal Culpability for
Sleep-Related Violence 653
Michel A. Cramer-Bornemann and
Mark W. Mahowald
66 Legal Obligations of Persons Who Have
Sleep Disorders or Who Treat or Hire
Them 661
Daniel B. Brown
67 Legal Aspects of Fatigue- and
Safety-Sensitive Professions 666
Daniel B. Brown and Jeffrey Masor
68 Sleep Medicine Clinical Practice and
Compliance—United States 670
Daniel B. Brown
69 Sleep Medicine Clinical Practice and
Compliance—Europe 675
Thomas Penzel
Section 10
Occupational Sleep Medicine 679
70 Introduction 679
Gregory Belenky, Torbjörn Åkerstedt, and
Nancy J. Wesensten
71 Performance Defcits During Sleep Loss
and Their Operational Consequences 682
Hans P.A. Van Dongen, Thomas J. Balkin, and
Steven R. Hursh
72 Sleep and Performance Prediction
Modeling 689
Steven R. Hursh, Thomas J. Balkin, and
Hans P.A. Van Dongen
73 Fatigue Risk Management Systems 697
Philippa H. Gander, Lora J. Wu,
Margo van den Berg, Amanda Lamp,
Laura Hoeg, and Gregory Belenky
74 Drowsiness in Transportation Workers 708
Pierre Philip, Patricia Sagaspe, and
Jacques Taillard
75 Shift Work, Shift-Work Disorder, and
Jet Lag 714
Christopher L. Drake and Kenneth P. Wright, Jr.
76 Sleep Problems in First Responders and
in Deployed Military Personnel 726
Bryan Vila, Charles Samuels, and
Nancy J. Wesensten
77 Sleep, Occupational Stress, and Burnout 736
Torbjörn Åkerstedt, Aleksander Perski, and
Göran Kecklund
78 Optimizing Shift Scheduling 742
Göran Kecklund, Mikael Sallinen, and
John Axelsson
79 Obstructive Sleep Apnea in the
Workplace 750
Chunbai Zhang, Mark B. Berger, Albert Rielly,
Atul Malhotra, and Stefanos N. Kales
Section 11
Insomnia 757
80 Insomnia: Recent Developments and
Future Directions 757
Daniel J. Buysse and Allison G. Harvey
81 Insomnia: Epidemiology and Risk Factors 761
Kenneth L. Lichstein, Daniel J. Taylor,
Christina S. McCrae, and Megan E. Petrov
82 Etiology and Pathophysiology of Insomnia 769
Michael Lloyd Perlis, Jason Gordon Ellis, Jacqueline
DeMichele Kloss, and Dieter Wilhelm Riemannxlii Contents
83 Insomnia Diagnosis, Assessment, and
Evaluation 785
Jason C. Ong, J. Todd Arnedt, and
Philip R. Gehrman
84 Insomnia and Health 794
Martica H. Hall, Julio Fernandez-Mendoza,
Christopher E. Kline, and Alexandros N. Vgontzas
85 Cognitive Behavior Therapies for
Insomnia I: Approaches and Efcacy 804
Charles M. Morin, Judith R. Davidson, and
Simon Beaulieu-Bonneau
86 Psychological and Behavioral Treatments
for Insomnia II: Implementation and
Specifc Populations 814
Jack D. Edinger, Melanie K. Leggett,
Colleen E. Carney, and Rachel Manber
87 Pharmacologic Treatment of Insomnia:
Benzodiazepine Receptor Agonists 832
James K. Walsh and Thomas Roth
88 Pharmacologic Treatment of Insomnia:
Other Medications 842
Andrew D. Krystal
Section 12
Neurologic Disorders 855
89 Narcolepsy: Genetics, Immunology, and
Pathophysiology 855
Emmanuel Mignot
90 Narcolepsy: Diagnosis and Management 873
Michelle T. Cao and Christian Guilleminault
91 Idiopathic Hypersomnia 883
Yves Dauvilliers and Claudio L. Bassetti
92 Parkinsonism 892
Claudia Trenkwalder, Isabelle Arnulf, and
Ronald Postuma
93 Sleep and Stroke 903
Claudio L. Bassetti
94 Sleep and Neuromuscular Diseases 916
Michelle T. Cao and Christian Guilleminault
95 Restless Legs Syndrome and Periodic
Limb Movements During Sleep 923
Richard P. Allen, Jacques Montplaisir,
Arthur Scott Walters, Luigi Ferini-Strambi,
and Birgit Högl
96 Alzheimer Disease and Other Dementias 935
Dominique Petit, Jacques Montplaisir,
Erik K. St. Louis, and Bradley F. Boeve
97 Epilepsy, Sleep, and Sleep Disorders 944
Milena K. Pavlova and Sanjeev V. Kothare
98 Other Neurologic Disorders 951
Antonio Culebras
99 Sleep Disorders After Traumatic Brain
Injury 959
Philipp O. Valko and Christian R. Baumann
100 Kleine-Levin Syndrome 969
Isabelle Arnulf
Section 13
Parasomnias 977
101 Parasomnias: Overview and Approach 977
Bradley V. Vaughn
102 Non–Rapid Eye Movement Parasomnias:
Clinical Spectrum, Diagnostic Features,
and Management 981
Alon Y. Avidan
103 Rapid Eye Movement Sleep Parasomnias 993
Michael H. Silber, Erik K. St. Louis, and
Bradley F. Boeve
104 Nightmares and Dream Disturbances 1002
Isabelle Arnulf
105 Other Parasomnias 1011
Alex Iranzo
106 Sleep-Related Movement Disorders and
Their Unique Motor Manifestations 1020
Rachel E. Salas, Seema Gulyani,
Anthony B. Kwan, and Charlene E. Gamaldo
Section 14
Sleep Breathing Disorders 1030
107 Sleep Related Breathing Disorders:
Classifcation 1030
Richard B. Berry
108 Sleep Breathing Disorders: Clinical
Overview 1041
Reena Mehra, Douglas E. Moul, and
Kingman P. Strohl
109 Central Sleep Apnea: Defnitions,
Pathophysiology, Genetics, and
Epidemiology 1049
Madalina Macrea, Eliot S. Katz, and
Atul Malhotra
110 Central Sleep Apnea: Diagnosis and
Management 1059
Andrey V. Zinchuk and Robert Joseph Thomas
111 Anatomy and Physiology of Upper
Airway Obstruction 1076
James A. Rowley and M. Safwan Badr
112 Snoring and Pathologic Upper Airway
Resistance Syndromes 1088
Riccardo Stoohs and Avram R. GoldContents xliii
113 Obstructive Sleep Apnea: Phenotypes
and Genetics 1102
Susan Redline
114 Obstructive Sleep Apnea: Clinical
Features, Evaluation, and Principles
of Management 1110
Harly Greenberg, Viera Lakticova, and
Steven M. Scharf
115 Positive Airway Pressure Treatment
for Obstructive Sleep Apnea 1125
Neil Freedman
116 Medical and Device Treatment for
Obstructive Sleep Apnea: Alternative,
Adjunctive, and Complementary
Therapies 1138
Susheel P. Patil, Ephraim Winocur,
Luis Buenaver, and Michael T. Smith
117 Obstructive Sleep Apnea and the
Central Nervous System: Neural Adaptive
Processes, Cognition, and Performance 1154
Ivana Rosenzweig, Terri E. Weaver, and
Mary J. Morrell
118 Obstructive Sleep Apnea and Metabolic
Disorders 1167
Mary Sau-Man Ip
119 Overlap Syndromes of Sleep and
Breathing Disorders 1179
Jose M. Marin and Santiago J. Carrizo
120 Obesity-Hypoventilation Syndrome 1189
Babak Mokhlesi
121 Obstructive Sleep Apnea, Obesity,
and Bariatric Surgery 1200
Eric J. Olson and Anita P. Courcoulas
122 Sleep and Breathing at High Altitude 1211
Vahid Mohsenin, Shahrokh Javaheri, and
Jerome A. Dempsey
Section 15
Cardiovascular Disorders 1222
123 Sleep and Cardiovascular Disease: Present
and Future 1222
Shahrokh Javaheri, Luciano F. Drager, and
Geraldo Lorenzi-Filho
124 Sleep-Related Cardiac Risk 1229
Richard L. Verrier and Murray A. Mittleman
125 Cardiac Arrhythmogenesis During Sleep:
Mechanisms, Diagnosis, and Therapy 1237
Richard L. Verrier and Mark E. Josephson
126 Cardiovascular Effects of Sleep-Related
Breathing Disorders 1243
Virend K. Somers and Shahrokh Javaheri
127 Systemic and Pulmonary Hypertension
in Obstructive Sleep Apnea 1253
F. Javier Nieto, Terry Young, Paul E. Peppard,
and Shahrokh Javaheri
128 Coronary Artery Disease and Obstructive
Sleep Apnea 1264
Yüksel Peker, Karl A. Franklin, and Jan Hedner
129 Heart Failure 1271
Shahrokh Javaheri
Section 16
Other Medical Disorders 1286
130 Sleep and Fatigue in Cancer Patients 1286
Josée Savard, Marie-Hélène Savard, and
Sonia Ancoli-Israel
131 Fibromyalgia and Chronic Fatigue
Syndromes 1294
Christine Won and Douglas Kirsch
132 Endocrine Disorders 1300
Adriana G. Ioachimescu and
Octavian C. Ioachimescu
133 Pain and Sleep 1313
Anthony G. Doufas
134 Sleep and Chronic Kidney Disease 1323
John G. Park and Kannan Ramar
135 Sleep in the Critically Ill Patient 1329
Siavash Farshidpanah, Margaret A. Pisani,
E. Wesley Ely, and Paula L. Watson
Section 17
Psychiatric Disorders 1341
136 Anxiety Disorders and Posttraumatic
Stress Disorder 1341
Andrew D. Krystal, Murray B. Stein, and
Steven T. Szabo
137 Unipolar Major Depression 1352
Jared D. Minkel, Andrew D. Krystal, and
Ruth M. Benca
138 Bipolar Disorder 1363
Allison G. Harvey, Adriane M. Soehner,
and Daniel J. Buysse
139 Schizophrenia 1370
Kathleen L. Benson and Irwin Feinberg
140 Medication and Substance Abuse 1380
Timothy Roehrs and Thomas Roth
141 Sleep Disturbances in Attention-Defcit/
Hyperactivity Disorder 1390
Samuele Cortese and Michel Lecendreuxxliv Contents
152 Obstructive Sleep Apnea in Older Adults 1496
Barbara A. Phillips
153 Insomnia in Older Adults 1503
Tamar Shochat and Sonia Ancoli-Israel
154 Circadian Rhythms in Older Adults 1510
Gregory J. Tranah, Katie L. Stone, and
Sonia Ancoli-Israel
Section 20
Sleep in Women 1516
155 Sex Differences and Menstrual-Related
Changes in Sleep and Circadian Rhythms 1516
Fiona C. Baker and Louise M. O’Brien
156 Sleep and Sleep Disorders Associated
with Pregnancy 1525
Bilgay Izci Balserak and Kathryn Aldrich Lee
157 Sleep-Disordered Breathing in Pregnancy 1540
Francesca Facco, Judette Louis,
Melissa Pauline Knauert, and
Bilgay Izci Balserak
158 Postpartum Period and Early
Motherhood 1547
Robyn Stremler, Katherine M. Sharkey,
and Amy R. Wolfson
159 Sleep and Menopause 1553
Fiona C. Baker, Hadine Joffe, and
Kathryn Aldrich Lee
Section 21
Instrumentation and Methodology 1564
160 Polysomnography and Beyond 1564
Max Hirshkowitz
161 Sleep Stage Scoring 1567
Sharon Keenan and Max Hirshkowitz
162 Central Nervous System Arousals and
Cyclic Alternating Patterns 1576
Liborio Parrino and Mario Giovanni Terzano
163 Neurologic Monitoring Techniques 1588
Beth A. Malow
164 Monitoring Techniques for Evaluating
Suspected Sleep-Related Breathing
Disorders 1598
Max Hirshkowitz and Meir Kryger
165 Home Sleep Testing 1610
Thomas Penzel
166 Cardiopulmonary Coupling Sleep
Spectrograms 1615
Robert Joseph Thomas
Section 18
Dentistry and Otolaryngology in
Sleep Medicine 1398
142 Role of Dentistry and Otolaryngology
in Sleep Medicine 1398
Gilles Lavigne, Michael Simmons, Nelly Huynh,
Fernanda R. Almeida, and Olivier M. Vanderveken
143 Oropharyngeal Growth and Skeletal
Malformations 1401
Stacey Dagmar Quo, Benjamin T. Pliska, and
Nelly Huynh
144 Sleep Bruxism: Defnition, Prevalence,
Classifcation, Etiology, and
Consequences 1423
Peter Svensson, Taro Arima, Gilles Lavigne,
and Eduardo Castrillon
145 Sleep Bruxism: Diagnostic Considerations 1427
Frank Lobbezoo, Kiyoshi Koyano,
Daniel A. Paesani, and Daniele Manfredini
146 Orofacial Pain and Temporomandibular
Disorders in Relation to Sleep-Disordered
Breathing and Sleep Bruxism 1435
Gregory K. Essick, Karen G. Raphael,
Anne E. Sanders, and Gilles Lavigne
147 Oral Appliances for the Treatment of
Obstructive Sleep Apnea–Hypopnea
Syndrome and for Concomitant Sleep
Bruxism 1445
Christopher J. Lettieri, Fernanda R. Almeida,
Peter A. Cistulli, and Maria Clotilde Carra
148 Anesthesia in Upper Airway Surgery
for Obstructive Sleep Apnea 1458
David R. Hillman, Peter R. Eastwood, and
Olivier M. Vanderveken
149 Upper Airway Surgery to Treat
Obstructive Sleep-Disordered Breathing 1463
Olivier M. Vanderveken, Aarnoud Hoekema,
and Edward M. Weaver
150 Pharmacotherapy, Complementary,
and Alternative Medicine for Sleep
Bruxism 1478
Ephraim Winocur, Luis Buenaver,
Susheel P. Patil, and Michael T. Smith
Section 19
Sleep in Older Adults 1484
151 Psychiatric and Medical Comorbidities
and Effects of Medications in Older
Adults 1484
Steven R. Barczi and Mihai C. TeodorescuContents xlv
170 Chronobiologic Monitoring Techniques 1659
John H. Herman
171 Actigraphy 1671
Katie L. Stone and Sonia Ancoli-Israel
Index 167
27 Genetics and Genomics of Circadian
Clocks 272
Martha Hotz Vitaterna, Fred W. Turek, and
Peng Jiang
28 Genetics and Genomic Basis of Sleep
in Simple Model Organisms 281
Ravi Allada and Mark Wu
29 Genetics and Genomic Basis of Sleep in
Rodents 296
Bruce F. O’Hara, Peng Jiang, Fred W. Turek,
and Paul Franken
30 Genetics and Genomic Basis of Sleep in
Healthy Humans 310
Hans-Peter Landolt and Derk-Jan Dijk
31 Genetics and Genomic Basis of Sleep
Disorders in Humans 322
Allan I. Pack, Brendan T. Keenan, Enda M. Byrne,
and Philip R. Gehrman
Section 5
Chronobiology 340
32 Introduction: Master Circadian Clock
and Master Circadian Rhythm 340
Fred W. Turek and Phyllis C. Zee
33 Anatomy of the Mammalian Circadian
System 343
Joshua J. Gooley and Clifford B. Saper
34 Physiology of the Mammalian Circadian
System 351
Alan M. Rosenwasser and Fred W. Turek
35 Human Circadian Timing System and
Sleep-Wake Regulation 362
Charles A. Czeisler and Orfeu M. Buxton
36 Sleep Homeostasis and Models of Sleep
Regulation 377
Peter Achermann and Alexander A. Borbély
37 Circadian Rhythms in Sleepiness,
Alertness, and Performance 388
Rylie J. Gabehart and Hans P.A. Van Dongen
38 Central and Peripheral Circadian Clocks 396
Edith Grosbellet and Etienne Challet
39 Circadian Dysregulation in Mental and
Physical Health 405
Sabra M. Abbott, Roneil G. Malkani, and
Phyllis C. Zee
40 Circadian Disorders of the Sleep-Wake
Cycle 414
Sabra M. Abbott, Kathryn J. Reid, and
Phyllis C. Zee
Section 6
Pharmacology 424
41 Hypnotic Medications: Mechanisms of
Action and Pharmacologic Effects 424
Thomas S. Kilduff and Wallace B. Mendelson
42 Clinical Pharmacology of Other Drugs
Used as Hypnotics 432
Daniel J. Buysse and Shachi Tyagi
43 Wake-Promoting Medications: Basic
Mechanisms and Pharmacology 446
Seiji Nishino and Emmanuel Mignot
44 Wake-Promoting Medications: Efcacy
and Adverse Effects 462
Mihaela Bazalakova and Ruth M. Benca
45 Drugs that Disturb Sleep and Wakefulness 480
Paula K. Schweitzer and Angela C. Randazzo
46 Effects of Hypnotic Drugs on Driving
Performance 499
Joris C. Verster, Aurora J.A.E. van de Loo,
and Thomas Roth
Section 7
Psychobiology and Dreaming 506
47 Introduction 506
Robert Stickgold
48 Why We Dream 509
Robert Stickgold and Erin J. Wamsley
49 Dream Content: Quantitative Findings 515
Antonio Zadra and G. William Domhoff
50 Brain Correlates of Successful Dream
Recall 523
Luigi De Gennaro and Michele Ferrara
51 Neurobiology of Dreaming 529
Edward F. Pace-Schott and Dante Picchioni
52 Lucid Dreaming 539
Martin Dresler, Daniel Erlacher, Michael Czisch,
and Victor I. Spoormaker
53 Nightmares and Nightmare Function 546
Tore Nielsen and Michelle Carr
54 Incorporation of Waking Experiences
into Dreams 555
Michael Schredl
55 Dreams and Nightmares in
Posttraumatic Stress Disorder 561
Wilfred R. Pigeon and Thomas A. Mellman
56 Emotion, Motivation, and Reward in
Relation to Dreaming 567
Sophie Schwartz and Lampros PerogamvrosContents xli
PAR T II
Practice of Sleep Medicine 571
Section 8
Impact, Presentation, and Diagnosis 573
57 Approach to the Patient with Disordered
Sleep 573
Beth A. Malow
58 Cardinal Manifestations of Sleep
Disorders 576
Bradley V. Vaughn and O’Neill F. D’Cruz
59 Physical Examination in Sleep Medicine 587
Alon Y. Avidan and Meir Kryger
60 Use of Clinical Tools and Tests in Sleep
Medicine 607
Cathy A. Goldstein and Ronald D. Chervin
61 Classifcation of Sleep Disorders 618
Michael J. Sateia and Michael J. Thorpy
62 Epidemiology of Sleep Medicine 627
Amy W. Amara and Mary Halsey Maddox
63 Sleep Medicine, Public Policy, and
Public Health 638
Raghu Pishka Upender
64 Sleep and Athletic Performance 646
Scott J. Kutscher
Section 9
Legal Topics in Sleep Medicine 653
65 Sleep Forensics: Criminal Culpability for
Sleep-Related Violence 653
Michel A. Cramer-Bornemann and
Mark W. Mahowald
66 Legal Obligations of Persons Who Have
Sleep Disorders or Who Treat or Hire
Them 661
Daniel B. Brown
67 Legal Aspects of Fatigue- and
Safety-Sensitive Professions 666
Daniel B. Brown and Jeffrey Masor
68 Sleep Medicine Clinical Practice and
Compliance—United States 670
Daniel B. Brown
69 Sleep Medicine Clinical Practice and
Compliance—Europe 675
Thomas Penzel
Section 10
Occupational Sleep Medicine 679
70 Introduction 679
Gregory Belenky, Torbjörn Åkerstedt, and
Nancy J. Wesensten
71 Performance Defcits During Sleep Loss
and Their Operational Consequences 682
Hans P.A. Van Dongen, Thomas J. Balkin, and
Steven R. Hursh
72 Sleep and Performance Prediction
Modeling 689
Steven R. Hursh, Thomas J. Balkin, and
Hans P.A. Van Dongen
73 Fatigue Risk Management Systems 697
Philippa H. Gander, Lora J. Wu,
Margo van den Berg, Amanda Lamp,
Laura Hoeg, and Gregory Belenky
74 Drowsiness in Transportation Workers 708
Pierre Philip, Patricia Sagaspe, and
Jacques Taillard
75 Shift Work, Shift-Work Disorder, and
Jet Lag 714
Christopher L. Drake and Kenneth P. Wright, Jr.
76 Sleep Problems in First Responders and
in Deployed Military Personnel 726
Bryan Vila, Charles Samuels, and
Nancy J. Wesensten
77 Sleep, Occupational Stress, and Burnout 736
Torbjörn Åkerstedt, Aleksander Perski, and
Göran Kecklund
78 Optimizing Shift Scheduling 742
Göran Kecklund, Mikael Sallinen, and
John Axelsson
79 Obstructive Sleep Apnea in the
Workplace 750
Chunbai Zhang, Mark B. Berger, Albert Rielly,
Atul Malhotra, and Stefanos N. Kales
Section 11
Insomnia 757
80 Insomnia: Recent Developments and
Future Directions 757
Daniel J. Buysse and Allison G. Harvey
81 Insomnia: Epidemiology and Risk Factors 761
Kenneth L. Lichstein, Daniel J. Taylor,
Christina S. McCrae, and Megan E. Petrov
82 Etiology and Pathophysiology of Insomnia 769
Michael Lloyd Perlis, Jason Gordon Ellis, Jacqueline
DeMichele Kloss, and Dieter Wilhelm Riemannxlii Contents
83 Insomnia Diagnosis, Assessment, and
Evaluation 785
Jason C. Ong, J. Todd Arnedt, and
Philip R. Gehrman
84 Insomnia and Health 794
Martica H. Hall, Julio Fernandez-Mendoza,
Christopher E. Kline, and Alexandros N. Vgontzas
85 Cognitive Behavior Therapies for
Insomnia I: Approaches and Efcacy 804
Charles M. Morin, Judith R. Davidson, and
Simon Beaulieu-Bonneau
86 Psychological and Behavioral Treatments
for Insomnia II: Implementation and
Specifc Populations 814
Jack D. Edinger, Melanie K. Leggett,
Colleen E. Carney, and Rachel Manber
87 Pharmacologic Treatment of Insomnia:
Benzodiazepine Receptor Agonists 832
James K. Walsh and Thomas Roth
88 Pharmacologic Treatment of Insomnia:
Other Medications 842
Andrew D. Krystal
Section 12
Neurologic Disorders 855
89 Narcolepsy: Genetics, Immunology, and
Pathophysiology 855
Emmanuel Mignot
90 Narcolepsy: Diagnosis and Management 873
Michelle T. Cao and Christian Guilleminault
91 Idiopathic Hypersomnia 883
Yves Dauvilliers and Claudio L. Bassetti
92 Parkinsonism 892
Claudia Trenkwalder, Isabelle Arnulf, and
Ronald Postuma
93 Sleep and Stroke 903
Claudio L. Bassetti
94 Sleep and Neuromuscular Diseases 916
Michelle T. Cao and Christian Guilleminault
95 Restless Legs Syndrome and Periodic
Limb Movements During Sleep 923
Richard P. Allen, Jacques Montplaisir,
Arthur Scott Walters, Luigi Ferini-Strambi,
and Birgit Högl
96 Alzheimer Disease and Other Dementias 935
Dominique Petit, Jacques Montplaisir,
Erik K. St. Louis, and Bradley F. Boeve
97 Epilepsy, Sleep, and Sleep Disorders 944
Milena K. Pavlova and Sanjeev V. Kothare
98 Other Neurologic Disorders 951
Antonio Culebras
99 Sleep Disorders After Traumatic Brain
Injury 959
Philipp O. Valko and Christian R. Baumann
100 Kleine-Levin Syndrome 969
Isabelle Arnulf
Section 13
Parasomnias 977
101 Parasomnias: Overview and Approach 977
Bradley V. Vaughn
102 Non–Rapid Eye Movement Parasomnias:
Clinical Spectrum, Diagnostic Features,
and Management 981
Alon Y. Avidan
103 Rapid Eye Movement Sleep Parasomnias 993
Michael H. Silber, Erik K. St. Louis, and
Bradley F. Boeve
104 Nightmares and Dream Disturbances 1002
Isabelle Arnulf
105 Other Parasomnias 1011
Alex Iranzo
106 Sleep-Related Movement Disorders and
Their Unique Motor Manifestations 1020
Rachel E. Salas, Seema Gulyani,
Anthony B. Kwan, and Charlene E. Gamaldo
Section 14
Sleep Breathing Disorders 1030
107 Sleep Related Breathing Disorders:
Classifcation 1030
Richard B. Berry
108 Sleep Breathing Disorders: Clinical
Overview 1041
Reena Mehra, Douglas E. Moul, and
Kingman P. Strohl
109 Central Sleep Apnea: Defnitions,
Pathophysiology, Genetics, and
Epidemiology 1049
Madalina Macrea, Eliot S. Katz, and
Atul Malhotra
110 Central Sleep Apnea: Diagnosis and
Management 1059
Andrey V. Zinchuk and Robert Joseph Thomas
111 Anatomy and Physiology of Upper
Airway Obstruction 1076
James A. Rowley and M. Safwan Badr
112 Snoring and Pathologic Upper Airway
Resistance Syndromes 1088
Riccardo Stoohs and Avram R. GoldContents xliii
113 Obstructive Sleep Apnea: Phenotypes
and Genetics 1102
Susan Redline
114 Obstructive Sleep Apnea: Clinical
Features, Evaluation, and Principles
of Management 1110
Harly Greenberg, Viera Lakticova, and
Steven M. Scharf
115 Positive Airway Pressure Treatment
for Obstructive Sleep Apnea 1125
Neil Freedman
116 Medical and Device Treatment for
Obstructive Sleep Apnea: Alternative,
Adjunctive, and Complementary
Therapies 1138
Susheel P. Patil, Ephraim Winocur,
Luis Buenaver, and Michael T. Smith
117 Obstructive Sleep Apnea and the
Central Nervous System: Neural Adaptive
Processes, Cognition, and Performance 1154
Ivana Rosenzweig, Terri E. Weaver, and
Mary J. Morrell
118 Obstructive Sleep Apnea and Metabolic
Disorders 1167
Mary Sau-Man Ip
119 Overlap Syndromes of Sleep and
Breathing Disorders 1179
Jose M. Marin and Santiago J. Carrizo
120 Obesity-Hypoventilation Syndrome 1189
Babak Mokhlesi
121 Obstructive Sleep Apnea, Obesity,
and Bariatric Surgery 1200
Eric J. Olson and Anita P. Courcoulas
122 Sleep and Breathing at High Altitude 1211
Vahid Mohsenin, Shahrokh Javaheri, and
Jerome A. Dempsey
Section 15
Cardiovascular Disorders 1222
123 Sleep and Cardiovascular Disease: Present
and Future 1222
Shahrokh Javaheri, Luciano F. Drager, and
Geraldo Lorenzi-Filho
124 Sleep-Related Cardiac Risk 1229
Richard L. Verrier and Murray A. Mittleman
125 Cardiac Arrhythmogenesis During Sleep:
Mechanisms, Diagnosis, and Therapy 1237
Richard L. Verrier and Mark E. Josephson
126 Cardiovascular Effects of Sleep-Related
Breathing Disorders 1243
Virend K. Somers and Shahrokh Javaheri
127 Systemic and Pulmonary Hypertension
in Obstructive Sleep Apnea 1253
F. Javier Nieto, Terry Young, Paul E. Peppard,
and Shahrokh Javaheri
128 Coronary Artery Disease and Obstructive
Sleep Apnea 1264
Yüksel Peker, Karl A. Franklin, and Jan Hedner
129 Heart Failure 1271
Shahrokh Javaheri
Section 16
Other Medical Disorders 1286
130 Sleep and Fatigue in Cancer Patients 1286
Josée Savard, Marie-Hélène Savard, and
Sonia Ancoli-Israel
131 Fibromyalgia and Chronic Fatigue
Syndromes 1294
Christine Won and Douglas Kirsch
132 Endocrine Disorders 1300
Adriana G. Ioachimescu and
Octavian C. Ioachimescu
133 Pain and Sleep 1313
Anthony G. Doufas
134 Sleep and Chronic Kidney Disease 1323
John G. Park and Kannan Ramar
135 Sleep in the Critically Ill Patient 1329
Siavash Farshidpanah, Margaret A. Pisani,
E. Wesley Ely, and Paula L. Watson
Section 17
Psychiatric Disorders 1341
136 Anxiety Disorders and Posttraumatic
Stress Disorder 1341
Andrew D. Krystal, Murray B. Stein, and
Steven T. Szabo
137 Unipolar Major Depression 1352
Jared D. Minkel, Andrew D. Krystal, and
Ruth M. Benca
138 Bipolar Disorder 1363
Allison G. Harvey, Adriane M. Soehner,
and Daniel J. Buysse
139 Schizophrenia 1370
Kathleen L. Benson and Irwin Feinberg
140 Medication and Substance Abuse 1380
Timothy Roehrs and Thomas Roth
141 Sleep Disturbances in Attention-Defcit/
Hyperactivity Disorder 1390
Samuele Cortese and Michel Lecendreuxxliv Contents
152 Obstructive Sleep Apnea in Older Adults 1496
Barbara A. Phillips
153 Insomnia in Older Adults 1503
Tamar Shochat and Sonia Ancoli-Israel
154 Circadian Rhythms in Older Adults 1510
Gregory J. Tranah, Katie L. Stone, and
Sonia Ancoli-Israel
Section 20
Sleep in Women 1516
155 Sex Differences and Menstrual-Related
Changes in Sleep and Circadian Rhythms 1516
Fiona C. Baker and Louise M. O’Brien
156 Sleep and Sleep Disorders Associated
with Pregnancy 1525
Bilgay Izci Balserak and Kathryn Aldrich Lee
157 Sleep-Disordered Breathing in Pregnancy 1540
Francesca Facco, Judette Louis,
Melissa Pauline Knauert, and
Bilgay Izci Balserak
158 Postpartum Period and Early
Motherhood 1547
Robyn Stremler, Katherine M. Sharkey,
and Amy R. Wolfson
159 Sleep and Menopause 1553
Fiona C. Baker, Hadine Joffe, and
Kathryn Aldrich Lee
Section 21
Instrumentation and Methodology 1564
160 Polysomnography and Beyond 1564
Max Hirshkowitz
161 Sleep Stage Scoring 1567
Sharon Keenan and Max Hirshkowitz
162 Central Nervous System Arousals and
Cyclic Alternating Patterns 1576
Liborio Parrino and Mario Giovanni Terzano
163 Neurologic Monitoring Techniques 1588
Beth A. Malow
164 Monitoring Techniques for Evaluating
Suspected Sleep-Related Breathing
Disorders 1598
Max Hirshkowitz and Meir Kryger
165 Home Sleep Testing 1610
Thomas Penzel
166 Cardiopulmonary Coupling Sleep
Spectrograms 1615
Robert Joseph Thomas
Section 18
Dentistry and Otolaryngology in
Sleep Medicine 1398
142 Role of Dentistry and Otolaryngology
in Sleep Medicine 1398
Gilles Lavigne, Michael Simmons, Nelly Huynh,
Fernanda R. Almeida, and Olivier M. Vanderveken
143 Oropharyngeal Growth and Skeletal
Malformations 1401
Stacey Dagmar Quo, Benjamin T. Pliska, and
Nelly Huynh
144 Sleep Bruxism: Defnition, Prevalence,
Classifcation, Etiology, and
Consequences 1423
Peter Svensson, Taro Arima, Gilles Lavigne,
and Eduardo Castrillon
145 Sleep Bruxism: Diagnostic Considerations 1427
Frank Lobbezoo, Kiyoshi Koyano,
Daniel A. Paesani, and Daniele Manfredini
146 Orofacial Pain and Temporomandibular
Disorders in Relation to Sleep-Disordered
Breathing and Sleep Bruxism 1435
Gregory K. Essick, Karen G. Raphael,
Anne E. Sanders, and Gilles Lavigne
147 Oral Appliances for the Treatment of
Obstructive Sleep Apnea–Hypopnea
Syndrome and for Concomitant Sleep
Bruxism 1445
Christopher J. Lettieri, Fernanda R. Almeida,
Peter A. Cistulli, and Maria Clotilde Carra
148 Anesthesia in Upper Airway Surgery
for Obstructive Sleep Apnea 1458
David R. Hillman, Peter R. Eastwood, and
Olivier M. Vanderveken
149 Upper Airway Surgery to Treat
Obstructive Sleep-Disordered Breathing 1463
Olivier M. Vanderveken, Aarnoud Hoekema,
and Edward M. Weaver
150 Pharmacotherapy, Complementary,
and Alternative Medicine for Sleep
Bruxism 1478
Ephraim Winocur, Luis Buenaver,
Susheel P. Patil, and Michael T. Smith
Section 19
Sleep in Older Adults 1484
151 Psychiatric and Medical Comorbidities
and Effects of Medications in Older
Adults 1484
Steven R. Barczi and Mihai C. TeodorescuContents xlv
170 Chronobiologic Monitoring Techniques 1659
John H. Herman
171 Actigraphy 1671
Katie L. Stone and Sonia Ancoli-Israel
Index 167